UniPR1331 is a 3β-hydroxy-Δ5-choline acid derivative that inhibits Eph-ephrin interactions. UniPR1331 interacts with VEGFR2 and blocks the interaction of VEGFR2 with its natural ligand vascular endothelial growth factor and subsequent autophosphorylation, signal transduction, and pro-angiogenic activation of endothelial cells in vitro. UniPR1331 also inhibits tumor cell-driven angiogenesis in zebrafish.

Physicochemical Properties

Molecular Formula	C35H48N2O4
Molecular Weight	560.77
CAS #	1809170-59-9
SMILES	O[C@H]1CC[C@@]2(C)C(C1)=CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)CCC(N[C@H](C(=O)O)CC3=CNC4C=CC=CC3=4)=O)CC[C@H]21
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Cholenic acid derivative UniPR1331 impairs tumor angiogenesis via blockade of VEGF/VEGFR2 in addition to Eph/ephrin. Cancer Gene Ther. 2022 Jul;29(7):908-917.

Solubility Data

Solubility (In Vitro)

DMSO : ~25 mg/mL (~44.58 mM; with ultrasonication)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.7833 mL	8.9163 mL	17.8326 mL
	5 mM	0.3567 mL	1.7833 mL	3.5665 mL
	10 mM	0.1783 mL	0.8916 mL	1.7833 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.