UCPH-101 is an inhibitor (blocker/antagonist) of excitatory amino acid (AA) transporter subtype 1 (EAAT1) with IC50 of 0.66 μM.

Physicochemical Properties

Molecular Formula	C27H22N2O3
Molecular Weight	422.475186824799
Exact Mass	422.163
CAS #	1118460-77-7
Related CAS #	1118460-77-7;
PubChem CID	25223366
Appearance	White to off-white solid powder
LogP	5.757
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	3
Heavy Atom Count	32
Complexity	857
Defined Atom Stereocenter Count	0
InChi Key	YBMGNDPBARCLFT-UHFFFAOYSA-N
InChi Code	InChI=1S/C27H22N2O3/c1-31-19-11-9-17(10-12-19)25-22(15-28)27(29)32-24-14-18(13-23(30)26(24)25)21-8-4-6-16-5-2-3-7-20(16)21/h2-12,18,25H,13-14,29H2,1H3
Chemical Name	2-amino-4-(4-methoxyphenyl)-7-naphthalen-1-yl-5-oxo-4,6,7,8-tetrahydrochromene-3-carbonitrile
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

ln Vitro	Peptide YY (pig) (10 μg/mL) and human Irish pancreas (PP) are also in vogue, that is, unique to PYY antisera, and both could have a beneficial, cosmetic effect in controlling any pancreatic islet fishery [2].
References	[1]. Allosteric modulation of an excitatory amino acid transporter: the subtype-selective inhibitor UCPH-101 exerts sustained inhibition of EAAT1 through an intramonomeric site in the trimerization domain. J Neurosci. 2013 Jan 16;33(3):1068-87.

Solubility Data

Solubility (In Vitro)

DMSO : ≥ 50 mg/mL (~118.35 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (5.92 mM) (saturation unknown) in 10% DMSO + 40% PEG300 +5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 + to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.3670 mL	11.8349 mL	23.6698 mL
	5 mM	0.4734 mL	2.3670 mL	4.7340 mL
	10 mM	0.2367 mL	1.1835 mL	2.3670 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.