UBP608 is a potent negative allosteric modulator (NAM) of N-Methyl-D-aspartate receptors (NMDARs). UBP608 may be utilized in neurological disease study.

Physicochemical Properties

Molecular Formula	C10H5BRO4
Molecular Weight	269.05
Exact Mass	267.937
CAS #	2199-87-3
PubChem CID	694463
Appearance	White to light yellow solid powder
Density	1.874g/cm3
Boiling Point	439ºC at 760mmHg
Melting Point	195-198 °C(lit.)
Flash Point	219.3ºC
Vapour Pressure	1.76E-08mmHg at 25°C
LogP	2.253
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	1
Heavy Atom Count	15
Complexity	336
Defined Atom Stereocenter Count	0
InChi Key	XFQHPAXNKDYMOX-UHFFFAOYSA-N
InChi Code	InChI=1S/C10H5BrO4/c11-6-1-2-8-5(3-6)4-7(9(12)13)10(14)15-8/h1-4H,(H,12,13)
Chemical Name	6-bromo-2-oxochromene-3-carboxylic acid
Synonyms	UBP 608; UBP-608; UBP608
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

ln Vitro	GluN1/GluN2A, GluN1/GluN2B, GluN1/GluN2C, and GluN1/GluN2D are all inhibited by UBP608 (100 µM), with respective inhibition rates of 89.3%, 63.5%, 56.1%, and 23.6% [1].
References	[1]. Coumarin-3-carboxylic acid derivatives as potentiators and inhibitors of recombinant and native N-methyl-D-aspartate receptors. Neurochem Int. 2012 Sep;61(4):593-600.

Solubility Data

Solubility (In Vitro)

DMSO : ~250 mg/mL (~929.20 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.08 mg/mL (7.73 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.7168 mL	18.5839 mL	37.1678 mL
	5 mM	0.7434 mL	3.7168 mL	7.4336 mL
	10 mM	0.3717 mL	1.8584 mL	3.7168 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.