Tisolagiline (KDS2010) is a reversible MAO-B inhibitor used in Parkinson's disease (PD) research.

Physicochemical Properties

Molecular Formula	C18H21F3N2O4S
Molecular Weight	418.430554151535
Exact Mass	322.129
CAS #	1894207-44-3
PubChem CID	132023446
Appearance	White to off-white solid powder
LogP	3.1
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	5
Heavy Atom Count	23
Complexity	384
Defined Atom Stereocenter Count	1
SMILES	S(C)(=O)(=O)O.FC(C1C=CC(=CC=1)C1C=CC(=CC=1)CN[C@H](C(N)=O)C)(F)F
InChi Key	XCUXYNYVUMLDKH-NSHDSACASA-N
InChi Code	InChI=1S/C17H17F3N2O/c1-11(16(21)23)22-10-12-2-4-13(5-3-12)14-6-8-15(9-7-14)17(18,19)20/h2-9,11,22H,10H2,1H3,(H2,21,23)/t11-/m0/s1
Chemical Name	(2S)-2-[[4-[4-(trifluoromethyl)phenyl]phenyl]methylamino]propanamide
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	MAO-B[1]
References	[1]. KDS2010, a Newly Developed Reversible MAO-B Inhibitor, as an Effective Therapeutic Candidate for Parkinson's Disease. Neurotherapeutics. 2021 Jul;18(3):1729-1747.

Solubility Data

Solubility (In Vitro)

DMSO: 100 mg/mL (310.25 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (7.76 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.3899 mL	11.9494 mL	23.8989 mL
	5 mM	0.4780 mL	2.3899 mL	4.7798 mL
	10 mM	0.2390 mL	1.1949 mL	2.3899 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.