Telomerase-IN-3 is an inhibitor of telomerase that directly targets hTERT promoter activity. In order to keep telomerase activity active, hTERT is essential.

Physicochemical Properties

Molecular Formula	C19H16CLN5O3
Molecular Weight	397.82
Exact Mass	397.09
CAS #	150096-77-8
PubChem CID	24834263
Appearance	Off-white to light yellow solid powder
LogP	3.9
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	4
Heavy Atom Count	28
Complexity	544
Defined Atom Stereocenter Count	0
SMILES	C(NC(NC1=CC=C(OC2=NC=C(Cl)C=N2)C(C)=C1)=O)(=O)C1=CC=CC=C1N
InChi Key	NLVSCQFSPVSAOF-UHFFFAOYSA-N
InChi Code	InChI=1S/C19H16ClN5O3/c1-11-8-13(6-7-16(11)28-19-22-9-12(20)10-23-19)24-18(27)25-17(26)14-4-2-3-5-15(14)21/h2-10H,21H2,1H3,(H2,24,25,26,27)
Chemical Name	2-amino-N-[[4-(5-chloropyrimidin-2-yl)oxy-3-methylphenyl]carbamoyl]benzamide
Synonyms	Telomerase-IN-3
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. hTERT MODULATORS AND METHODS OF USE. WO2017095969A1.

Solubility Data

Solubility (In Vitro)

DMSO : ~25 mg/mL (~62.8 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (6.28 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.5137 mL	12.5685 mL	25.1370 mL
	5 mM	0.5027 mL	2.5137 mL	5.0274 mL
	10 mM	0.2514 mL	1.2568 mL	2.5137 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.