TC AQP1 1 (m-Phenylenediacrylic acid) is a potent AQP1 inhibitor. TC AQP1 1 inhibits AQP1-mediated oocyte water flux with IC50 of 8 μM.

Physicochemical Properties

Molecular Formula	C12H10O4
Molecular Weight	218.208
Exact Mass	218.058
Elemental Analysis	C, 66.05; H, 4.62; O, 29.33
CAS #	37710-81-9
PubChem CID	794091
Appearance	White to off-white solid powder
LogP	1.882
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	4
Heavy Atom Count	16
Complexity	287
Defined Atom Stereocenter Count	0
SMILES	C1(/C=C/C(O)=O)C=CC=C(/C=C/C(O)=O)C=1
InChi Key	KRXUBZPHAPGHPE-YDFGWWAZSA-N
InChi Code	InChI=1S/C12H10O4/c13-11(14)6-4-9-2-1-3-10(8-9)5-7-12(15)16/h1-8H,(H,13,14)(H,15,16)/b6-4+,7-5+
Chemical Name	(E)-3-[3-[(E)-2-carboxyethenyl]phenyl]prop-2-enoic acid
Synonyms	TC-AQP1-1TC-AQP 1-1TC-AQP-1-1
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Recent breakthroughs and future directions in drugging aquaporins. Trends Pharmacol Sci. 2022 Jan;43(1):30-42.

Solubility Data

Solubility (In Vitro)

DMSO : ~50 mg/mL (~229.14 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (11.46 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	4.5827 mL	22.9137 mL	45.8274 mL
	5 mM	0.9165 mL	4.5827 mL	9.1655 mL
	10 mM	0.4583 mL	2.2914 mL	4.5827 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.