Squalane, found in some fish oils (especially shark liver oil) and some vegetable oils, is a saturated analogue of Squalene. Squalane has anti-cancer and antioxidant effects. Squalane is widely used as a skin moisturizer and emollient.

Physicochemical Properties

Molecular Formula	C30H62
Molecular Weight	422.81328
Exact Mass	422.485
CAS #	111-01-3
Related CAS #	Squalane-d62;16514-83-3
PubChem CID	8089
Appearance	Colorless to light yellow liquid
Density	0.8±0.1 g/cm3
Boiling Point	470.3±0.0 °C at 760 mmHg
Melting Point	−38 °C(lit.)
Flash Point	217.8±0.0 °C
Vapour Pressure	0.0±0.5 mmHg at 25°C
Index of Refraction	1.448
LogP	15.59
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	0
Rotatable Bond Count	21
Heavy Atom Count	30
Complexity	308
Defined Atom Stereocenter Count	0
SMILES	CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C
InChi Key	PRAKJMSDJKAYCZ-UHFFFAOYSA-N
InChi Code	InChI=1S/C30H62/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h25-30H,9-24H2,1-8H3
Chemical Name	2,6,10,15,19,23-hexamethyltetracosane
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

ln Vitro	Squalane exhibits significant promise for the pharmaceutical and nutraceutical sectors. In vitro and animal models, squalane has been shown to exhibit anticancer, antioxidant, drug carrier, detoxifying, skin moisturizing, and emollient properties [1].
References	[1]. Biological importance and applications of squalene and squalane. Adv Food Nutr Res. 2012;65:223-33.
Additional Infomation	Squalane has been reported in Murraya paniculata with data available.

Solubility Data

Solubility (In Vitro)

DMSO : ~100 mg/mL (~236.50 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (5.91 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (5.91 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 2.5 mg/mL (5.91 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.3651 mL	11.8256 mL	23.6513 mL
	5 mM	0.4730 mL	2.3651 mL	4.7303 mL
	10 mM	0.2365 mL	1.1826 mL	2.3651 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.