SN-008 is a low activity analog of SN-011 and can be used as a negative control (NC).

Physicochemical Properties

Molecular Formula	C25H19FN2O3S
Molecular Weight	446.493368387222
Exact Mass	446.11
CAS #	2249106-01-0
PubChem CID	138005723
Appearance	White to off-white solid powder
LogP	5
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	6
Heavy Atom Count	32
Complexity	703
Defined Atom Stereocenter Count	0
SMILES	S(C1C=CC(=CC=1)F)(NC1C=CC=C(C=1)NC(C1C=CC(=CC=1)C1C=CC=CC=1)=O)(=O)=O
InChi Key	GFQARWFKDMDSAS-UHFFFAOYSA-N
InChi Code	InChI=1S/C25H19FN2O3S/c26-21-13-15-24(16-14-21)32(30,31)28-23-8-4-7-22(17-23)27-25(29)20-11-9-19(10-12-20)18-5-2-1-3-6-18/h1-17,28H,(H,27,29)
Chemical Name	N-[3-[(4-fluorophenyl)sulfonylamino]phenyl]-4-phenylbenzamide
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. STING inhibitors target the cyclic dinucleotide binding pocket. Proc Natl Acad Sci U S A. 2021 Jun 15;118(24):e2105465118.

Solubility Data

Solubility (In Vitro)

DMSO: 100 mg/mL (223.97 mM)

Solubility (In Vivo)

Solubility in Formulation 1: 2.5 mg/mL (5.60 mM) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.2397 mL	11.1985 mL	22.3969 mL
	5 mM	0.4479 mL	2.2397 mL	4.4794 mL
	10 mM	0.2240 mL	1.1198 mL	2.2397 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.