SIRT1-IN-4 (Compound 8c) is a SIRT1 inhibitor with IC50 of 10.04 μM. SIRT1-IN-4 can be used in cancer research.

Physicochemical Properties

Molecular Formula	C25H18O7
Molecular Weight	430.41
CAS #	445405-18-5
Appearance	Solid powder
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	SIRT1 10.04 μM (IC50)
References	[1]. Discovery of 5-Benzylidene-2-phenyl-1,3-dioxane-4,6-diones as Highly Potent and Selective SIRT1 Inhibitors. ACS Med Chem Lett. 2021 Mar 1;12(3):397-403.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.3234 mL	11.6168 mL	23.2337 mL
	5 mM	0.4647 mL	2.3234 mL	4.6467 mL
	10 mM	0.2323 mL	1.1617 mL	2.3234 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.