3CLPro-IN-3 (Compound A36) is an inhibitor of SARS-CoV-2 3CLpro with IC50 of 51.3 nM. 3CLPro-IN-3 exhibits antiviral activity against human coronavirus 229E, OC43 and murine coronavirus MHV.

Physicochemical Properties

Molecular Formula	C25H22CLF3N8O2
Molecular Weight	558.94
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Development of pyrimidone derivatives as nonpeptidic and noncovalent 3-chymotrypsin-like protease (3CLpro) inhibitors with anti-coronavirus activities. Bioorg Chem. 2024 Nov 22;154:107988.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.7891 mL	8.9455 mL	17.8910 mL
	5 mM	0.3578 mL	1.7891 mL	3.5782 mL
	10 mM	0.1789 mL	0.8946 mL	1.7891 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.