(S)-AM-9022 is the S-enantiomer of AM-9022. AM-9022 is an orally active, potent and selective KIF18A inhibitor for cancer research.

Physicochemical Properties

Molecular Formula	C27H36F2N6O4S
Molecular Weight	578.67
CAS #	2446872-47-3
Related CAS #	AM-9022;2446872-46-2
Appearance	White to off-white solid powder
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Small-molecule inhibition of kinesin KIF18A reveals a mitotic vulnerability enriched in chromosomally unstable cancers. Nat Cancer. 2023 Dec 27.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.7281 mL	8.6405 mL	17.2810 mL
	5 mM	0.3456 mL	1.7281 mL	3.4562 mL
	10 mM	0.1728 mL	0.8641 mL	1.7281 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.