Ras Inhibitory Peptide (VPPPVPPRRR) is a Ras inhibitor with antitumor activity.

Physicochemical Properties

Molecular Formula	C53H91N19O11
Molecular Weight	1170.41
CAS #	159088-48-9
SMILES	CC([C@H](N)C(N1CCC[C@H]1C(N2CCC[C@H]2C(N3CCC[C@H]3C(N[C@H](C(N4CCC[C@H]4C(N5CCC[C@H]5C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)=O)=O)C(C)C)=O)=O)=O)=O)C
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

ln Vitro	Ras inhibitory peptide (VPPPVPPRRR; 5 μM) inhibits HUVEC migration and abolishes the preventive effect of 30 μM geranyl alcohol (FOH) on 60 μM terbinafine-mediated inhibition of HUVEC migration [1].
References	[1]. Terbinafine inhibits endothelial cell migration through suppression of the Rho-mediated pathway. Mol Cancer Ther. 2006 Dec;5(12):3130-8.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	0.8544 mL	4.2720 mL	8.5440 mL
	5 mM	0.1709 mL	0.8544 mL	1.7088 mL
	10 mM	0.0854 mL	0.4272 mL	0.8544 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.