Variabilin (Homopisatin) is a potent RGD-containing glycoprotein IIb-IIIa and platelet aggregation antagonist from the hard tick Dermacentor variabilis. Variabilin can effectively inhibit platelet aggregation induced by the platelet agonist ADP, collagen, and the thrombin receptor peptide SFLLRNP. Variabilin can also block platelet adhesion to immobilized Fg. In addition, Variabilin inhibits the binding of purified human GPIIb-IIIa to immobilized Fg.

Physicochemical Properties

Molecular Formula	C17H16O5
Molecular Weight	300.31
CAS #	3187-52-8
SMILES	COC1C=CC2[C@H]3OC4C=C(C=CC=4[C@@]3(O)COC=2C=1)OC
Synonyms	Homopisatin
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Variabilin, a novel RGD-containing antagonist of glycoprotein IIb-IIIa and platelet aggregation inhibitor from the hard tick Dermacentor variabilis. J Biol Chem. 1996 Jul 26;271(30):17785-90. [2]. Variabilin, a 6a-hydroxypterocarpan from Dalbergia variabilisJ. Phytochemistry, 1978, 17(8): 1417-1418.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.3299 mL	16.6495 mL	33.2989 mL
	5 mM	0.6660 mL	3.3299 mL	6.6598 mL
	10 mM	0.3330 mL	1.6649 mL	3.3299 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.