 Chemical Structure.png)
Physicochemical Properties
| Molecular Formula | C75H126N24O15 |
| Molecular Weight | 1603.95474 |
| Exact Mass | 1602.983 |
| CAS # | 72957-38-1 |
| PubChem CID | 25075996 |
| Appearance | White to off-white solid powder |
| Density | 1.4±0.1 g/cm3 |
| Index of Refraction | 1.645 |
| LogP | -0.5 |
| Hydrogen Bond Donor Count | 22 |
| Hydrogen Bond Acceptor Count | 21 |
| Rotatable Bond Count | 54 |
| Heavy Atom Count | 114 |
| Complexity | 3160 |
| Defined Atom Stereocenter Count | 12 |
| SMILES | CCC(C(NC(C(NC(C(NC(C(NC(C(NC(CNC(CNC(C(N)CC1=CC=C(O)C=C1)=O)=O)=O)CC2=CC=CC=C2)=O)CC(C)C)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)C(NC(C(N3CCCC3C(NC(C(NC(C(NC(C(O)=O)CCCCN)=O)CC(C)C)=O)CCCCN)=O)=O)CCCNC(N)=N)=O)C |
| InChi Key | OVVIBUHLQIYUEU-IWIISZHXSA-N |
| InChi Code | InChI=1S/C75H126N24O15/c1-7-45(6)61(70(111)94-53(25-17-35-87-75(83)84)71(112)99-36-18-26-58(99)69(110)93-50(21-11-13-31-76)64(105)96-56(38-44(4)5)67(108)95-54(72(113)114)22-12-14-32-77)98-65(106)52(24-16-34-86-74(81)82)91-63(104)51(23-15-33-85-73(79)80)92-66(107)55(37-43(2)3)97-68(109)57(40-46-19-9-8-10-20-46)90-60(102)42-88-59(101)41-89-62(103)49(78)39-47-27-29-48(100)30-28-47/h8-10,19-20,27-30,43-45,49-58,61,100H,7,11-18,21-26,31-42,76-78H2,1-6H3,(H,88,101)(H,89,103)(H,90,102)(H,91,104)(H,92,107)(H,93,110)(H,94,111)(H,95,108)(H,96,105)(H,97,109)(H,98,106)(H,113,114)(H4,79,80,85)(H4,81,82,86)(H4,83,84,87)/t45-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,61-/m0/s1 |
| Chemical Name | (2S)-6-amino-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]hexanoic acid |
| Synonyms | Porcine dynorphin A(1-13); Dynorphin A Porcine Fragment 1-13 |
| HS Tariff Code | 2934.99.9001 |
| Storage |
Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition | Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs) |
Biological Activity
| Targets | κ Opioid Receptor/KOR |
| ln Vitro | Dynorphin A (1-13) exposure (33 μM) causes a discernible destruction of neuronal morphology at 16 hours, and a substantial loss of neuronal viability at 4 hours. Individual neurons' acute [Ca2+]i increases in response to dynorphin A (1–13) exposure are comparable to those observed following acute NMDA treatment.Over time, dynorphin A (1–13) (100 μM) exposure consistently results in a notable loss of neurons[1]. |
| ln Vivo | Dynorphin A (1-13) exposure (33 μM) resulted in a significant loss of neuronal viability at 4 hours and a significant disruption of neuronal morphology at 16 hours. Exposure to dynorphin A (1-13) results in a dramatic increase in [Ca2+]i in single neurons, similar to the increase seen with acute NMDA treatment. Sustained exposure to dynorphin A (1-13) (100 μM) results in significant neuronal loss over time [1]. |
| References |
[1]. Dynorphin A (1-13) neurotoxicity in vitro: opioid and non-opioid mechanisms in mouse spinal cord neurons. Exp Neurol. 1999 Dec;160(2):361-75. |
Solubility Data
| Solubility (In Vitro) | H2O: ≥ 60 mg/mL (~37.4 mM) |
| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (62.35 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 0.6235 mL | 3.1173 mL | 6.2346 mL | |
| 5 mM | 0.1247 mL | 0.6235 mL | 1.2469 mL | |
| 10 mM | 0.0623 mL | 0.3117 mL | 0.6235 mL |