Nikethamide is one of the respiratory center activators and may be utilized in the research/study of respiratory failure.

Physicochemical Properties

Molecular Formula	C10H14N2O
Molecular Weight	178.23
Exact Mass	178.11
CAS #	59-26-7
PubChem CID	5497
Appearance	Colorless to light yellow liquid（Density：1.06 g/cm3 ）
Density	1.0±0.1 g/cm3
Boiling Point	298.0±0.0 °C at 760 mmHg
Melting Point	23 °C(lit.)
Flash Point	141.1±20.4 °C
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.520
LogP	0.33
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	3
Heavy Atom Count	13
Complexity	166
Defined Atom Stereocenter Count	0
SMILES	O=C(C1=C([H])N=C([H])C([H])=C1[H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
Synonyms	beta-PyrimidumAnacardone Astrocar Anacordone
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Simultaneous determination of nikethamide and lidocaine in human blood and cerebrospinal fluid by high performance liquid chromatography. J Pharm Biomed Anal. 2007 Apr 11;43(5):1757-62.

Additional Infomation

Nicethamid appears as clear light yellow viscous liquid or crystalline solid. Slightly bitter taste followed by a faint sensation of the warmth. (NTP, 1992) Nikethamide is a pyridinecarboxamide. It is functionally related to a nicotinamide. Nikethamide has been reported in Corydalis with data available. A central nervous system stimulant. It was formerly used in the treatment of barbiturate overdose but is now considered to be of no value for such purposes and may be dangerous. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1229)

Solubility Data

Solubility (In Vitro)	H2O : ≥ 50 mg/mL (~280.54 mM) DMSO : ≥ 1 mg/mL (~5.61 mM)
Solubility (In Vivo)	Solubility in Formulation 1: 100 mg/mL (561.07 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	5.6107 mL	28.0536 mL	56.1073 mL
	5 mM	1.1221 mL	5.6107 mL	11.2215 mL
	10 mM	0.5611 mL	2.8054 mL	5.6107 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.