Nifursol (Salfuride; Nifursol; Histomon) is a livestock feed additive and antiobiotic agent that has been extensively used for the prevention of histomoniasis (black head disease) in turkeys.
Physicochemical Properties
| Molecular Formula | C12H7N5O9 |
| Molecular Weight | 365.21 |
| Exact Mass | 365.024 |
| Elemental Analysis | C, 39.47; H, 1.93; N, 19.18; O, 39.43 |
| CAS # | 16915-70-1 |
| Related CAS # | Nifursol-13C6 |
| PubChem CID | 9570327 |
| Appearance | Light yellow to yellow solid powder |
| Density | 1.87 g/cm3 |
| Melting Point | 215-220ºC (dec.) |
| Index of Refraction | 1.742 |
| LogP | 3.434 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 10 |
| Rotatable Bond Count | 3 |
| Heavy Atom Count | 26 |
| Complexity | 610 |
| Defined Atom Stereocenter Count | 0 |
| SMILES | O=C(N/N=C/C1=CC=C([N+]([O-])=O)O1)C2=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C2O |
| InChi Key | XXUXXCZCUGIGPP-WLRTZDKTSA-N |
| InChi Code | InChI=1S/C12H7N5O9/c18-11-8(3-6(15(20)21)4-9(11)16(22)23)12(19)14-13-5-7-1-2-10(26-7)17(24)25/h1-5,18H,(H,14,19)/b13-5+ |
| Chemical Name | (E)-2-hydroxy-3,5-dinitro-N'-((5-nitrofuran-2-yl)methylene)benzohydrazide |
| Synonyms | Histomon; Nifursol; Salfuride |
| HS Tariff Code | 2934.99.9001 |
| Storage |
Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition | Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs) |
Biological Activity
| References |
[1]. Effect of cupric sulfate on the prophylactic efficacy of 2-acetylamino-5nitrothiazole, nifursol and ipronidazole against histomoniasis in turkeys. Poult Sci. 1971 Nov;50(6):1668-72. [2]. Detection, accumulation, distribution, and depletion of furaltadone and nifursol residues in poultry muscle, liver, and gizzard. J Agric Food Chem. 2011 Nov 23;59(22):11927-34. |
| Additional Infomation | Nifursol is a dinitrophenol, a nitrofuran antibiotic and a carbohydrazide. |
Solubility Data
| Solubility (In Vitro) | DMSO : ~50 mg/mL (~136.91 mM) |
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (6.85 mM) (saturation unknown) in 10% DMSO + 40% PEG300 +5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 + to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.7382 mL | 13.6908 mL | 27.3815 mL | |
| 5 mM | 0.5476 mL | 2.7382 mL | 5.4763 mL | |
| 10 mM | 0.2738 mL | 1.3691 mL | 2.7382 mL |