NCGC00537446 is a dual Nsp14 MTase/ExoN inhibitor. NCGC00537446 can be used to study SARS-CoV-2 replication and infection.

Physicochemical Properties

Molecular Formula	C22H26N6O3
Molecular Weight	422.48
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. A High-Throughput Screening Pipeline to Identify Methyltransferase and Exonuclease Inhibitors of SARS-CoV-2 NSP14. Biochemistry. 2025 Jan 21;64(2):419-431.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.3670 mL	11.8349 mL	23.6698 mL
	5 mM	0.4734 mL	2.3670 mL	4.7340 mL
	10 mM	0.2367 mL	1.1835 mL	2.3670 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.