Myristyl nicotinate (Tetradecyl nicotinate) is an ester precursor and lipophilic analogue of Nicotinic acid. Myristyl nicotinate was developed to deliver niacin into the skin to prevent actinic keratosis and its progression to skin cancer. Myristyl nicotinate has been shown to stimulate epidermal differentiation in photodamaged skin, increase skin NAD content and strengthen the human skin barrier.

Physicochemical Properties

Molecular Formula	C20H33NO2
Molecular Weight	319.4815
Exact Mass	319.251
CAS #	273203-62-6
PubChem CID	531641
Appearance	White to yellow solid powder
Density	0.953g/cm3
Boiling Point	411.7ºC at 760 mmHg
Flash Point	202.8ºC
Vapour Pressure	5.46E-07mmHg at 25°C
Index of Refraction	1.486
LogP	5.939
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	15
Heavy Atom Count	23
Complexity	281
Defined Atom Stereocenter Count	0
SMILES	O(C(C1=C([H])N=C([H])C([H])=C1[H])=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
InChi Key	TVGLGJWCZSCAEM-UHFFFAOYSA-N
InChi Code	InChI=1S/C20H33NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-17-23-20(22)19-15-14-16-21-18-19/h14-16,18H,2-13,17H2,1H3
Chemical Name	tetradecyl pyridine-3-carboxylate
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

ln Vitro

Myristyl niacin, also known as myristyl nicotinate, is used to treat and prevent skin barrier-damaging conditions like atopic dermatitis and chronic photodamage. It is also used to relieve the side effects of medications like steroids and retinoids that damage the skin barrier[2].

References

[1]. Catz P, et al. Simultaneous determination of myristyl nicotinate, nicotinic acid, and nicotinamide in rabbit plasma by liquid chromatography-tandem mass spectrometry using methyl ethyl ketone as a deproteinization solvent. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Dec 27;829(1-2):123-35. [2]. Jacobson MK, et al. Effect of myristyl nicotinate on retinoic acid therapy for facial photodamage. Exp Dermatol. 2007 Nov;16(11):927-35.

Solubility Data

Solubility (In Vitro)

DMSO : ~9.62 mg/mL (~30.11 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 0.96 mg/mL (3.00 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 9.6 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 0.96 mg/mL (3.00 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 9.6 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.1301 mL	15.6504 mL	31.3009 mL
	5 mM	0.6260 mL	3.1301 mL	6.2602 mL
	10 mM	0.3130 mL	1.5650 mL	3.1301 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.