Methyl camosate is a diterpene extracted from sage or rosemary that has potent antioxidant and anti-bacterial effect.

Physicochemical Properties

Molecular Formula	C21H30O4
Molecular Weight	346.461
Exact Mass	346.214
CAS #	82684-06-8
PubChem CID	11336941
Appearance	Light green to green solid powder
LogP	5.2
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	3
Heavy Atom Count	25
Complexity	514
Defined Atom Stereocenter Count	2
SMILES	COC(=O)[C@]12CCCC(C)(C)C1CCC3=C2C(=C(O)C(=C3)C(C)C)O
InChi Key	IIJLVJMZYPZQLW-YCRPNKLZSA-N
InChi Code	InChI=1S/C21H30O4/c1-12(2)14-11-13-7-8-15-20(3,4)9-6-10-21(15,19(24)25-5)16(13)18(23)17(14)22/h11-12,15,22-23H,6-10H2,1-5H3/t15-,21+/m0/s1
Chemical Name	methyl (4aR,10aS)-5,6-dihydroxy-1,1-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthrene-4a-carboxylate
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

ln Vitro	In relation to Bacillus cereus, methyl carnosate exhibits antibacterial action [2].
References	[1]. Antioxidant Constituents in Sage (Salvia officinalis). J. Agric. Food Chem. 1994, 42, 005-609 005. [2]. Methyl carnosate, an antibacterial diterpene isolated from Salvia officinalis leaves. Nat Prod Commun. 2013 Apr;8(4):429-30.
Additional Infomation	Methyl Carnosate has been reported in Salvia officinalis, Salvia, and Salvia lanigera with data available.

Solubility Data

Solubility (In Vitro)

DMSO : ~100 mg/mL (~288.63 mM) Ethanol : ~50 mg/mL (~144.32 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (7.22 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.8863 mL	14.4317 mL	28.8634 mL
	5 mM	0.5773 mL	2.8863 mL	5.7727 mL
	10 mM	0.2886 mL	1.4432 mL	2.8863 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.