Mavodelpar (REN001) is a novel and potent agonist of PPARδ. Mavodelpar inhibits renal fibrosis and glomerular damage. Research on long-chain fatty acid oxidation disorders (LC-FAOD) and primary mitochondrial myopathies (PMM) can benefit from the use of mavodelpar. Mavodelpar is a reagent for click chemistry that has an alkyne group.It can be used in the copper-catalyzed azide-alkyne cycloaddition (CuAAc) reaction with molecules that also have an azide group.

Physicochemical Properties

Molecular Formula	C31H29FNNAO5
Exact Mass	537.56
Elemental Analysis	C, 69.26; H, 5.44; F, 3.53; N, 2.61; Na, 4.28; O, 14.88
CAS #	1604815-32-8
Related CAS #	Mavodelpar free acid;942594-93-6
PubChem CID	122662515
Appearance	White to off-white solid powder
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	10
Heavy Atom Count	39
Complexity	834
Defined Atom Stereocenter Count	0
SMILES	CC1=C(C=CC(=C1)OC/C=C(\C2=CC=C(C=C2)C#CCN3CCOCC3)/C4=CC=C(C=C4)F)OCC(=O)[O-].[Na+]
InChi Key	FDJYWCAHISUZAI-MAOGHAJMSA-M
InChi Code	InChI=1S/C31H30FNO5.Na/c1-23-21-28(12-13-30(23)38-22-31(34)35)37-18-14-29(26-8-10-27(32)11-9-26)25-6-4-24(5-7-25)3-2-15-33-16-19-36-20-17-33;/h4-14,21H,15-20,22H2,1H3,(H,34,35);/q;+1/p-1/b29-14+;
Chemical Name	sodium;2-[4-[(E)-3-(4-fluorophenyl)-3-[4-(3-morpholin-4-ylprop-1-ynyl)phenyl]prop-2-enoxy]-2-methylphenoxy]acetate
Synonyms	HPP-593; HPP 593; HPP593; REN 001; REN-001; REN001
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

ln Vivo	Mavodelpar (10 mg/kg; intraperitoneal injection, 10 mg/kg, once daily, 6-17 weeks of age) can effectively suppress glomerular damage and renal fibrosis, and reduce the levels of fibrosis-related proteins [1].
Animal Protocol	Animal/Disease Models: Male and female B6129SF1-Col4a3-/- mice [1] Doses: 10 mg/kg Route of Administration: intraperitoneal (ip) injection; 10 mg/kg one time/day, 6 to 17 weeks of age Experimental Results: Inhibition of proteinuria and hematuria Burea nitrogen (BUN) level. Reduces glomerular injury, renal fibrosis, phosho-Stat3 and connective tissue growth factor (CTGF) levels. diminished expression levels of activated fibroblast marker α-SMA and collagen types I and IV.
References	[1]. PPARδ agonism ameliorates renal fibrosis in an Alport syndrome mouse model. Kidney360. 2022 Nov 29.

Solubility Data

Solubility (In Vitro)

DMSO: ~100 mg/mL (~186.0 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (4.65 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (4.65 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 2.5 mg/mL (4.65 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)