Martinostat is an HDAC inhibitor that can be radionuclide-labeled for quantitative imaging of HDACs in the central nervous system and major peripheral organs in vivo.

Physicochemical Properties

Molecular Formula	C22H30N2O2
Molecular Weight	354.49
CAS #	1629052-58-9
Related CAS #	Martinostat hydrochloride
SMILES	O=C(/C=C/C1C=CC(=CC=1)CN(C)CC12CC3CC(CC(C3)C1)C2)NO
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. In Vivo Imaging of Histone Deacetylases (HDACs) in the Central Nervous System and Major Peripheral Organs. J Med Chem. 2014 Oct 9;57(19):7999-8009. [2]. 11CMartinostat PET analysis reveals reduced HDAC I availability in Alzheimer’s disease. Nat Commun. 2022 Jul 19;13(1):4171.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.8210 mL	14.1048 mL	28.2095 mL
	5 mM	0.5642 mL	2.8210 mL	5.6419 mL
	10 mM	0.2821 mL	1.4105 mL	2.8210 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.