MOTS-c (mouse) is a mitochondrial-derived polypeptide that can be used to regulate pancreatic cell function. MOTS-c (mouse) reduces insulin secretion and expression in INS-1E cells and enhances glucagon secretion and expression in αTC-1 cells. MOTS-c (mouse) reduces apoptosis in INS-1E and αTC-1 cells. MOTS-c (mouse) counteracts diet-induced obesity and insulin resistance by activating AMPK.

Physicochemical Properties

Molecular Formula	C69H99N13O17S2
Molecular Weight	1446.73
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. MOTS-c regulates pancreatic alpha and beta cell functions in vitro. Histochem Cell Biol. 2024 Jun;161(6):449-460.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	0.6912 mL	3.4561 mL	6.9121 mL
	5 mM	0.1382 mL	0.6912 mL	1.3824 mL
	10 mM	0.0691 mL	0.3456 mL	0.6912 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.