MD-265 is a PROTAC degrader that degrades MDM2, leading to p53 activation in cancer cells carrying wild-type p53. MD-265 achieves complete tumor regression and improves long-term survival of leukemia mice. (Pink: MI-1063; Black: linker; Blue: Lenalidomide).

Physicochemical Properties

Molecular Formula	C50H51CL2FN6O6
Molecular Weight	921.88
CAS #	2415160-21-1
SMILES	ClC1C=CC2=C(C=1)NC([C@@]12[C@@H](C2C=CC=C(C=2F)Cl)[C@H](C(NC2CCC(C(N3CCC(C#CC4=CC=CC5C(N(C6C(NC(CC6)=O)=O)CC4=5)=O)CC3)=O)CC2)=O)NC21CCCCC2)=O
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Discovery of MD-265: A Potent MDM2 Degrader That Achieves Complete Tumor Regression and Improves Long-Term Survival of Mice with Leukemia. J Med Chem. 2024 Nov 14;67(21):19503-19518.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.0847 mL	5.4237 mL	10.8474 mL
	5 mM	0.2169 mL	1.0847 mL	2.1695 mL
	10 mM	0.1085 mL	0.5424 mL	1.0847 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.