MX69-102 (compound MX69-102) is a MDM-2/p53 inhibitor that induces MDM2 degradation, leading to p53 activation and cancer cell apoptosis. MX69-102 shows potent inhibitory effects on human MDM2-overexpressing ALL xenografts in SCID mice.

Physicochemical Properties

Molecular Formula	C29H30N2O5S
Molecular Weight	518.62
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. An MDM2 degrader shows potent cytotoxicity to MDM2-overexpressing acute lymphoblastic leukemia cells with minimal toxicity to normal cells/tissues. Cancer Lett. 2024 Aug 28;598:217126.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.9282 mL	9.6410 mL	19.2819 mL
	5 mM	0.3856 mL	1.9282 mL	3.8564 mL
	10 mM	0.1928 mL	0.9641 mL	1.9282 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.