LZ9 is an ATP-competitive inhibitor of CDK1 and CDK2. LZ9 has the potential to be used in colorectal cancer (CRC) research.

Physicochemical Properties

Molecular Formula	C17H11F3N4O2
Molecular Weight	360.29
CAS #	844441-29-8
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	CDK1 cyclin B1/CDC2
References	[1]. Computational design of CDK1 inhibitors with enhanced target affinity and drug-likeness using deep-learning framework. Heliyon. 2024 Nov 14;10(22):e40345. [2]. Computational identification of potential inhibitors targeting cdk1 in colorectal cancer. Front Chem. 2023 Nov 30;11:1264808.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.7755 mL	13.8777 mL	27.7554 mL
	5 mM	0.5551 mL	2.7755 mL	5.5511 mL
	10 mM	0.2776 mL	1.3878 mL	2.7755 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.