Physicochemical Properties
| Molecular Formula | C164H286N66O40 |
| Appearance | White to off-white solid |
| Synonyms | L-JNKI-1 |
| HS Tariff Code | 2934.99.9001 |
| Storage |
Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition | Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs) |
Biological Activity
| Targets | JNK |
| ln Vitro | In vivo tests with L-JNKI-1 have demonstrated its capability to successfully inhibit JNK activity. It has been demonstrated that Ang II causes a pressor response that is dose dependent and that is significantly suppressed by JNK inhibition[1]. The phosphorylation of c-Jun is found to be reduced by 10 μM L-JNKI-1 by 98%, and that of Elk-1 by 100%. Within 1 hour of an intraperitoneal injection, L-JNKI-1 can cross the blood-brain barrier and enter the neurons of adult mice and P5 rats[2]. |
| References |
[1]. Role of c-Jun N-terminal kinase in the regulation of vascular tone. J Cardiovasc Pharmacol Ther. 2010 Mar;15(1):78-83. [2]. A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia. Nat Med. 2003 Sep;9(9):1180-6. |
Solubility Data
| Solubility (In Vitro) | H2O: ≥ 100 mg/mL (~26.2 mM) |
| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (26.16 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication. (Please use freshly prepared in vivo formulations for optimal results.) |