KIF18A-IN-14 (Compound Example 81) is a KIF18A inhibitor. KIF18A-IN-14 has two forms, EX81-A and its enantiomer EX81-B. EX81-A and EX81-B inhibit OVCAR-3 cell viability with IC50 of 0-0.01 μM and 0.01-0.1 μM, respectively. KIF18A-IN-14 can be used in tumor research (e.g., colon cancer, breast cancer, lung cancer).

Physicochemical Properties

Molecular Formula	C26H32F3N5O6S
Molecular Weight	599.62
CAS #	3051552-75-8
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

ln Vitro	EX81-A and EX81-B inhibit OVCAR-3 cell viability with IC50 values of 0-0.01 μM and 0.01-0.1 μM, respectively[1].
References	[1]. Inhibitors of kif18a and uses thereof. WO2024153217.WIPO, 2024-01-19.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.6677 mL	8.3386 mL	16.6772 mL
	5 mM	0.3335 mL	1.6677 mL	3.3354 mL
	10 mM	0.1668 mL	0.8339 mL	1.6677 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.