Ipflufenoquin is an insecticide that has the potential to control primary infection of apple scab. Ipflufenoquin should be applied from half-inch green to fruit set.

Physicochemical Properties

Molecular Formula	C19H16F3NO2
Molecular Weight	347.33
Exact Mass	347.113
CAS #	1314008-27-9
PubChem CID	68289416
Appearance	Off-white to light yellow solid powder
LogP	4.1
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	3
Heavy Atom Count	25
Complexity	464
Defined Atom Stereocenter Count	0
SMILES	C1(CO)=C(F)C=C(C)C(C)=C1OC1C=C2C(=NC=1C)C(F)=C(F)C=C2
InChi Key	DSXOWZNZGWXWMX-UHFFFAOYSA-N
InChi Code	InChI=1S/C19H16F3NO2/c1-10-15(9-11-7-8-13(21)17(22)18(11)23-10)25-14-6-4-5-12(20)16(14)19(2,3)24/h4-9,24H,1-3H3
Chemical Name	2-[2-(7,8-difluoro-2-methylquinolin-3-yl)oxy-6-fluorophenyl]propan-2-ol
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1].Hirayama K. Curative effects of fungicides against Venturia inaequalis causing apple scab[J]. Journal of General Plant Pathology, 2022, 88(4): 264-269.

Additional Infomation

Ipflufenoquin is a member of the class of quinolines that is quinoline substituted by a methyl group, 3-fluoro-2-(2-hydroxypropan-2-yl)phenoxy group, fluoro group and fluoro group at positions 2, 3, 7 and 8, respectively. It is a fungicide being developed by Nippon-Soda Co. Ltd (Japan) which has stable efficacy against a wide range of plant diseases, such as gray mold, scab and rice blast. It has a role as a fungicide. It is a member of quinolines, an organofluorine compound, an aromatic ether and a member of benzyl alcohols.

Solubility Data

Solubility (In Vitro)

DMSO :~100 mg/mL (~287.91 mM; with sonication (<80°C))

Solubility (In Vivo)

Solubility in Formulation 1: 5 mg/mL (14.40 mM) in 10% DMSO + 40% PEG300 + 5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one),clear solution; with ultrasonication. For example, if 1 mL of working solution is to be prepared,you can add 100 μL of 50.0 mg/mL clear DMSO stock solution and add it to 400 μL PEG300 and mix well. Then add 50 μL Tween-80 to the above system and mix well. Then continue to add 450 μL of physiological saline to make up to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: 5 mg/mL (14.40 mM) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one),clear solution; with ultrasonication. For example, if 1 mL of working solution is to be prepared,you can add 100 μL of 50.0 mg/mL clear DMSO stock solution and add it to 900 μL corn oil and mix well.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.8791 mL	14.3955 mL	28.7911 mL
	5 mM	0.5758 mL	2.8791 mL	5.7582 mL
	10 mM	0.2879 mL	1.4396 mL	2.8791 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.