IRAK inhibitor 2 is an inhibitor (blocker/antagonist) of interleukin-1 receptor-associated kinase 4 (IRAK4). For more details, check and find patent WO 2008030579 A2.

Physicochemical Properties

Molecular Formula	C17H14N4O2
Molecular Weight	306.31866
Exact Mass	306.112
CAS #	928333-30-6
PubChem CID	135900142
Appearance	Light yellow to yellow solid powder
LogP	2.067
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	4
Heavy Atom Count	23
Complexity	389
Defined Atom Stereocenter Count	0
InChi Key	OPKXXSDVMPBIOF-UHFFFAOYSA-N
InChi Code	InChI=1S/C17H14N4O2/c22-13-5-3-12(4-6-13)15-11-19-17-8-7-16(20-21(15)17)18-10-14-2-1-9-23-14/h1-9,11,22H,10H2,(H,18,20)
Chemical Name	4-[6-(furan-2-ylmethylamino)imidazo[1,2-b]pyridazin-3-yl]phenol
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. WO2008030579A2.

Solubility Data

Solubility (In Vitro)

DMSO : ≥ 50 mg/mL (~163.23 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.75 mg/mL (8.98 mM) (saturation unknown) in 10% DMSO + 40% PEG300 +5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 27.5 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 + to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.2646 mL	16.3228 mL	32.6456 mL
	5 mM	0.6529 mL	3.2646 mL	6.5291 mL
	10 mM	0.3265 mL	1.6323 mL	3.2646 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.