Hydroxyethyl disulfide can block the inhibitory effect of showdomycin on dichloromethotrexate-resistant thymidylate synthase and can also be protected by its substrate deoxyuridylic acid to prevent the inactivation of the antibiotic.

Physicochemical Properties

Molecular Formula	C4H10O2S2
Molecular Weight	154.25
CAS #	1892-29-1
Appearance	Colorless to light yellow liquid（Density: 1.172 g/cm³）
SMILES	OCCSSCCO
Synonyms	2-Hydroxyethyl disulfide
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Kalman T I. Inhibition of thymidylate synthetase by showdomycin and its 5′-phosphate. Biochemical and Biophysical Research Communications, 1972, 49(4): 1007-1013.

Solubility Data

Solubility (In Vitro)

DMSO : ≥ 100 mg/mL (~648.30 mM)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	6.4830 mL	32.4149 mL	64.8298 mL
	5 mM	1.2966 mL	6.4830 mL	12.9660 mL
	10 mM	0.6483 mL	3.2415 mL	6.4830 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.