BFC1108 is a small molecule Bcl-2 functional switch. BFC1108 induces conformational changes in Bcl-2, resulting in exposure of its BH3 domain both in vitro and in vivo. BFC1108 can effectively induce apoptosis in cancer cells expressing Bcl-2.

Physicochemical Properties

Molecular Formula	C23H21CLN2O4
Molecular Weight	424.88
CAS #	692774-37-1
Appearance	Solid powder
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Identification and characterization of a small molecule Bcl-2 Functional Converter. Cancer Res Commun. 2024 Feb 8.

Solubility Data

Solubility (In Vitro)

DMSO : 100 mg/mL (235.36 mM; with sonication)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 5 mg/mL (11.77 mM)(saturation unknown) in 10% DMSO 40% PEG300 5% Tween-80 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution This solution produces a clear solution of ≥ 5 mg/mL (saturation unknown). For example, if 1 mL of working solution, add 100 μL of 50.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix well; then add 50 μL Tween-80 to the above system and mix well; then add 450 μL saline to make up to 1 mL. *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 5 mg/mL (11.77 mM)(Saturation unknown) in 10% DMSO 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution, add 100 μL of 50.0 mg/mL clear DMSO stock solution to 900 μL corn oil and mix well. (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.3536 mL	11.7680 mL	23.5361 mL
	5 mM	0.4707 mL	2.3536 mL	4.7072 mL
	10 mM	0.2354 mL	1.1768 mL	2.3536 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.