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Glucocorticoid receptor agonist-4 2842165-72-2

Glucocorticoid receptor agonist-4 2842165-72-2

CAS No.: 2842165-72-2

Glucocorticoid receptor agonist-4 (Compound Preparation 5) is a glucocorticoid receptor agonist that can be conjugated w
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This product is for research use only, not for human use. We do not sell to patients.

Glucocorticoid receptor agonist-4 (Compound Preparation 5) is a glucocorticoid receptor agonist that can be conjugated with TNF-α antibody for the study of autoimmune and inflammatory diseases.

Physicochemical Properties


CAS # 2842165-72-2
Appearance White to off-white solid powder
HS Tariff Code 2934.99.9001
Storage

Powder-20°C 3 years

4°C 2 years

In solvent -80°C 6 months

-20°C 1 month

Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light.
Shipping Condition Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity


References

[1].Human tumor necrosis factor alpha antibody glucocorticoid conjugates. Patent WO2023220549A1.


Solubility Data


Solubility (In Vitro) DMSO :~200 mg/mL (~323.78 mM; with sonication)
Solubility (In Vivo) Solubility in Formulation 1: ≥ 5 mg/mL (8.09 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one),clear solution.
For example, if 1 mL of working solution is to be prepared,you can add 100 μL of 50.0 mg/mL clear DMSO stock solution and add it to 400 μL PEG300 and mix well. Then add 50 μL Tween-80 to the above system and mix well. Then continue to add 450 μL of physiological saline to make up to 1 mL.
Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution.

 (Please use freshly prepared in vivo formulations for optimal results.)