3-Azidopropanol is a reagent for click chemistry bearing an azide (N3) moiety. Click chemistry has great application potential in the conjugation between nucleic acids, lipids, proteins and other molecules and has been applied in various research fields due to its beneficial properties such as high yield, high specificity and simplicity.

Physicochemical Properties

Molecular Formula	C3H7N3O
Molecular Weight	101.11
Exact Mass	101.059
CAS #	72320-38-8
PubChem CID	10996974
Appearance	Colorless to light yellow liquid
Density	1.095 g/cm3at 25°C (lit.)
Boiling Point	64 °C at 2 Torr (lit.)
Flash Point	87.77 °C - closed cup(lit.)
LogP	0.131
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Heavy Atom Count	7
Complexity	76.2
Defined Atom Stereocenter Count	0
SMILES	C(CN=[N+]=[N-])CO
InChi Key	WHVSIWLMCCGHFW-UHFFFAOYSA-N
InChi Code	InChI=1S/C3H7N3O/c4-6-5-2-1-3-7/h7H,1-3H2
Chemical Name	3-azidopropan-1-ol
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Recent applications of click chemistry in drug discovery. Expert Opin Drug Discov. 2019 Aug;14(8):779-789.

Solubility Data

Solubility (In Vitro)

DMSO : 100 mg/mL (989.02 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (24.73 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (24.73 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 2.5 mg/mL (24.73 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	9.8902 mL	49.4511 mL	98.9022 mL
	5 mM	1.9780 mL	9.8902 mL	19.7804 mL
	10 mM	0.9890 mL	4.9451 mL	9.8902 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.