Fenquizone (MG-13054) is a thiazide-like diuretic with chronic anti-hypertensive (blood pressure lowering) effects. Fenquizone may be utilized in study/research of edema and hypertension.

Physicochemical Properties

Molecular Formula	C21H29NO
Molecular Weight	311.469
Exact Mass	337.029
CAS #	20287-37-0
PubChem CID	68548
Appearance	Typically exists as solid at room temperature
Density	1.469g/cm3
Index of Refraction	1.644
LogP	4.089
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	2
Heavy Atom Count	22
Complexity	530
Defined Atom Stereocenter Count	0
SMILES	ClC1C=C2C(C(=O)NC(C3C=CC=CC=3)N2)=CC=1S(N)(=O)=O
InChi Key	DBDTUXMDTSTPQZ-UHFFFAOYSA-N
InChi Code	InChI=1S/C14H12ClN3O3S/c15-10-7-11-9(6-12(10)22(16,20)21)14(19)18-13(17-11)8-4-2-1-3-5-8/h1-7,13,17H,(H,18,19)(H2,16,20,21)
Chemical Name	7-chloro-4-oxo-2-phenyl-2,3-dihydro-1H-quinazoline-6-sulfonamide
Synonyms	M.G. 13054 MG13054 MG-13054 Fenquizone
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Additional Infomation

Fenquizone is a member of quinazolines. Fenquizone is a quinazolinone sulphonamide-based diuretic, structurally related to metolazone, with thiazide-like activity. As a thiazide-like diuretic, fenquizone acts by blocking reabsorption of sodium in the proximal tubule and the ascending branch of the loop of Henle. This causes an increase in diuresis with the elimination of chloride and sodium.

Solubility Data

Solubility (In Vitro)

DMSO : ~100 mg/mL (~296.05 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (7.40 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (7.40 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 2.5 mg/mL (7.40 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.2106 mL	16.0529 mL	32.1058 mL
	5 mM	0.6421 mL	3.2106 mL	6.4212 mL
	10 mM	0.3211 mL	1.6053 mL	3.2106 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.