FHT-1205 is a potent inhibitor of SMARCA4/SMARCA2 ATPase (BRG1 and BRM) with IC50 ≤10 nM (WO2020160180A1; compound 67).

Physicochemical Properties

Molecular Formula	C25H25N5O4S3
Molecular Weight	555.69
Exact Mass	555.106
CAS #	2368903-18-6
PubChem CID	139371523
Appearance	White to off-white solid powder
LogP	3.1
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	10
Heavy Atom Count	37
Complexity	880
Defined Atom Stereocenter Count	1
SMILES	N1(S(C)(=O)=O)C=CC(C(N[C@H](C(NC2=NC(C3=CC=CC(C4C=CN=CC=4)=C3)=CS2)=O)CCSC)=O)=C1
InChi Key	FAYSHZVDWADZMD-NRFANRHFSA-N
InChi Code	InChI=1S/C25H25N5O4S3/c1-35-13-9-21(27-23(31)20-8-12-30(15-20)37(2,33)34)24(32)29-25-28-22(16-36-25)19-5-3-4-18(14-19)17-6-10-26-11-7-17/h3-8,10-12,14-16,21H,9,13H2,1-2H3,(H,27,31)(H,28,29,32)/t21-/m0/s1
Chemical Name	N-[(2S)-4-methylsulfanyl-1-oxo-1-[[4-(3-pyridin-4-ylphenyl)-1,3-thiazol-2-yl]amino]butan-2-yl]-1-methylsulfonylpyrrole-3-carboxamide
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Compounds and uses thereof. WO2020160180A1.

Solubility Data

Solubility (In Vitro)

DMSO : ≥ 100 mg/mL (~179.96 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (4.50 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.7996 mL	8.9978 mL	17.9956 mL
	5 mM	0.3599 mL	1.7996 mL	3.5991 mL
	10 mM	0.1800 mL	0.8998 mL	1.7996 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.