Ethyl maltol (2-Ethyl-3-hydroxy-4H-pyran-4-one) is an odor-active compound, an important food additive, and the major component that gives food aroma.

Physicochemical Properties

Molecular Formula	C7H8O3
Molecular Weight	140.1366
Exact Mass	140.047
CAS #	4940-11-8
Related CAS #	Ethyl maltol-d5
PubChem CID	21059
Appearance	White to off-white solid powder
Density	1.3±0.1 g/cm3
Boiling Point	290.3±40.0 °C at 760 mmHg
Melting Point	85-95 °C(lit.)
Flash Point	124.8±20.8 °C
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.541
LogP	0.61
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	1
Heavy Atom Count	10
Complexity	213
Defined Atom Stereocenter Count	0
SMILES	O1C([H])=C([H])C(C(=C1C([H])([H])C([H])([H])[H])O[H])=O
InChi Key	YIKYNHJUKRTCJL-UHFFFAOYSA-N
InChi Code	InChI=1S/C7H8O3/c1-2-6-7(9)5(8)3-4-10-6/h3-4,9H,2H2,1H3
Chemical Name	2-ethyl-3-hydroxypyran-4-one
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Additional Infomation

Ethyl maltol is a pyranone. Ethyl maltol has been reported in Mangifera indica with data available.

Solubility Data

Solubility (In Vitro)

DMSO : ~100 mg/mL (~713.57 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.08 mg/mL (14.84 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (14.84 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 2.08 mg/mL (14.84 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	7.1357 mL	35.6786 mL	71.3572 mL
	5 mM	1.4271 mL	7.1357 mL	14.2714 mL
	10 mM	0.7136 mL	3.5679 mL	7.1357 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.