EGFR-IN-103 (compound 1) is a potent EGFR inhibitor with IC50 of 6 nM for pEGFR.

Physicochemical Properties

Molecular Formula	C28H24CL2FN7O2S
Molecular Weight	612.51
CAS #	2568506-66-9
SMILES	C(N1C=C2C(=CC(C3C=CC(N4CCOCC4)=CC=3)=C(C2=N1)Cl)Cl)(C1N=CN2C[C@@H](CC=12)F)C(=O)NC1SC=CN=1
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Ram W. Sabnis. Combination of Allosteric and Orthosteric EGFR Inhibitors for Treating Non-Small-Cell Lung Cancer. ACS Med. Chem. Lett. February 27, 2024.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.6326 mL	8.1631 mL	16.3263 mL
	5 mM	0.3265 mL	1.6326 mL	3.2653 mL
	10 mM	0.1633 mL	0.8163 mL	1.6326 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.