Dextran sulfate sodium salt (MW5000) is an anhydroglucose polymer with a molecular weight of 5000. Dextran sulfate sodium salt may be utilized to induce colitis. Dextran sulfate sodium salt can also inhibit the replication of human immunodeficiency virus by preventing the adsorption of the virus (HIV) into host cells.

Physicochemical Properties

Molecular Formula	C9H11NO2
Molecular Weight	165.189142465591
Exact Mass	165.078
CAS #	9011-18-1
Related CAS #	Dextran sulfate sodium salt (MW5000);9011-18-1;Dextran sulfate sodium salt (MW 4500-5500);9011-18-1;Dextran sulfate sodium salt (MW 16000-24000);9011-18-1;Dextran sulfate sodium salt (MW 35000-45000);9011-18-1
Appearance	Off-white to light yellow solid powder
LogP	1.9
SMILES	O(CC)C(C1C=CC(=CC=1)N)=O
InChi Key	BLFLLBZGZJTVJG-UHFFFAOYSA-N
InChi Code	InChI=1S/C9H11NO2/c1-2-12-9(11)7-3-5-8(10)6-4-7/h3-6H,2,10H2,1H3
Chemical Name	ethyl 4-aminobenzoate
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

ln Vitro	Complete protection of MT-4 cells against HIV-1-induced cytopathogenicity is provided by dextran sulfate (25 μg/mL) sodium salt[2].
ln Vivo	Models of colitis can be created in animals by using dextran sulfate sodium salt (MW5000).
References	[1]. Regmi S, et, al. Enhanced viability and function of mesenchymal stromal cell spheroids is mediated via autophagy induction. Autophagy. 2021 Oct;17(10):2991-3010. [2]. Baba M, et al. Mechanism of inhibitory effect of dextran sulfate and heparin on replication of human immunodeficiency virus in vitro. Proc Natl Acad Sci U S A. 1988 Aug;85(16):6132-6. [3]. Araki Y, et, al. Dextran sulfate sodium administered orally is depolymerized in the stomach and induces cell cycle arrest plus apoptosis in the colon in early mouse colitis. Oncol Rep. 2012 Nov;28(5):1597-605.

Solubility Data

Solubility (In Vitro)	H2O : 100 mg/mL
Solubility (In Vivo)	Solubility in Formulation 1: 33.33 mg/mL (Infinity mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	6.0536 mL	30.2682 mL	60.5364 mL
	5 mM	1.2107 mL	6.0536 mL	12.1073 mL
	10 mM	0.6054 mL	3.0268 mL	6.0536 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.