DL-alpha-Tocopherol methoxypolyethylene glycol succinate solution (TPGS-750-M) is an amphiphilic molecule that works as a hydrophilic and lipophilic surfactant.

Physicochemical Properties

Molecular Formula	C6H5F3N2
Molecular Weight	162.112511396408
Exact Mass	588.438
CAS #	1309573-60-1
Related CAS #	1309573-60-1
PubChem CID	149533007
Appearance	Colorless to light yellow liquid
Density	0.981 g/mL at 25 °C
LogP	10.4
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	21
Heavy Atom Count	42
Complexity	783
Defined Atom Stereocenter Count	0
SMILES	FC(C1C=C(C=CN=1)N)(F)F
InChi Key	ZMZHTFWPAUPDMZ-UHFFFAOYSA-N
InChi Code	InChI=1S/C36H60O6/c1-25(2)13-10-14-26(3)15-11-16-27(4)17-12-21-36(8)22-20-31-30(7)34(28(5)29(6)35(31)42-36)41-33(38)19-18-32(37)40-24-23-39-9/h25-27H,10-24H2,1-9H3
Chemical Name	1-O-(2-methoxyethyl) 4-O-[2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydrochromen-6-yl] butanedioate
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. TPGS-750-M: a second-generation amphiphile for metal-catalyzed cross-couplings in water at room temperature. J Org Chem. 2011 Jun 3;76(11):4379-91.

Solubility Data

Solubility (In Vitro)	H2O : ≥ 50 mg/mL
Solubility (In Vivo)	Solubility in Formulation 1: 25 mg/mL (Infinity mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with heating and sonication.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	6.1687 mL	30.8433 mL	61.6865 mL
	5 mM	1.2337 mL	6.1687 mL	12.3373 mL
	10 mM	0.6169 mL	3.0843 mL	6.1687 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.