DK1 is a potent modulator of estrogen-related receptors. DK1 has the ability to lower blood glucose and affects ERRα receptor activity. DK1 has potential in diabetes research.

Physicochemical Properties

Molecular Formula	C16H13CLN2O2
Molecular Weight	300.74
Exact Mass	300.066
CAS #	1187568-17-7
PubChem CID	44240655
Appearance	Off-white to yellow solid powder
LogP	3.1
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	2
Heavy Atom Count	21
Complexity	432
Defined Atom Stereocenter Count	0
SMILES	N1C2=C(C=CC(OC)=C2)C(=O)N(C)C=1C1=CC=C(Cl)C=C1
InChi Key	XNYBZAGNXXIAKK-UHFFFAOYSA-N
InChi Code	InChI=1S/C16H13ClN2O2/c1-19-15(10-3-5-11(17)6-4-10)18-14-9-12(21-2)7-8-13(14)16(19)20/h3-9H,1-2H3
Chemical Name	2-(4-chlorophenyl)-7-methoxy-3-methylquinazolin-4-one
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Computational investigation of the interaction mechanism between the estrogen related receptor α and its agonists.

Solubility Data

Solubility (In Vitro)

DMSO : ~25 mg/mL (~83.13 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (8.31 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.3251 mL	16.6257 mL	33.2513 mL
	5 mM	0.6650 mL	3.3251 mL	6.6503 mL
	10 mM	0.3325 mL	1.6626 mL	3.3251 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.