D-Ribose 5-phosphate disodium dihydrate is an intermediate product of the oxidative branch of the pentose phosphate pathway (PPP) and the final product of the non-oxidative branch of PPP. D-Ribose 5-phosphate may be used in the synthesis/preparation of nucleotides and nucleic acids.

Physicochemical Properties

Molecular Formula	C5H13NA2O10P
Molecular Weight	310.10
Exact Mass	273.983
CAS #	207671-46-3
Related CAS #	D-Ribose 5-phosphate disodium;18265-46-8;D-Ribose 5-phosphate;4300-28-1
PubChem CID	71310163
Appearance	White to yellow solid powder
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	5
Heavy Atom Count	18
Complexity	212
Defined Atom Stereocenter Count	3
SMILES	C([C@H]([C@H]([C@H](C=O)O)O)O)OP(=O)([O-])[O-].O.O.[Na+].[Na+]
InChi Key	ROFJYRUKQPRHKK-WFAHMUOKSA-L
InChi Code	InChI=1S/C5H11O8P.2Na.2H2O/c6-1-3(7)5(9)4(8)2-13-14(10,11)12;;;;/h1,3-5,7-9H,2H2,(H2,10,11,12);;;2*1H2/q;2*+1;;/p-2/t3-,4+,5-;;;;/m0..../s1
Chemical Name	disodium;[(2R,3R,4R)-2,3,4-trihydroxy-5-oxopentyl] phosphate;dihydrate
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	Human Endogenous Metabolite
ln Vitro	Most people believe that the oxidative and nonoxidative pentose phosphate pathways produce ribose-5-phosphate[1].
References	[1]. Ribose-5-phosphate biosynthesis in Methanocaldococcus jannaschii occurs in the absence of a pentose-phosphate pathway. J Bacteriol. 2005 Nov;187(21):7382-9.

Solubility Data

Solubility (In Vitro)	H2O: 100 mg/mL (322.48 mM) DMSO: 1 mg/mL (3.22 mM)
Solubility (In Vivo)	Solubility in Formulation 1: 50 mg/mL (161.24 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.2248 mL	16.1238 mL	32.2477 mL
	5 mM	0.6450 mL	3.2248 mL	6.4495 mL
	10 mM	0.3225 mL	1.6124 mL	3.2248 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.