D-Ribose 5-phosphate disodium is an intermediate product of the oxidative branch of the pentose phosphate pathway (PPP) and the final product of the non-oxidative branch of PPP. D-Ribose 5-phosphate disodium may be used in the synthesis/preparation of nucleotides and nucleic acids.

Physicochemical Properties

Molecular Formula	C5H9NA2O8P
Molecular Weight	274.07
Exact Mass	273.983
CAS #	18265-46-8
Related CAS #	D-Ribose 5-phosphate disodium dihydrate;207671-46-3;D-Ribose 5-phosphate;4300-28-1
PubChem CID	18646925
Appearance	White to off-white solid powder
Boiling Point	539.9ºC at 760mmHg
Flash Point	280.3ºC
Vapour Pressure	6.58E-14mmHg at 25°C
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	5
Heavy Atom Count	16
Complexity	212
Defined Atom Stereocenter Count	3
SMILES	C([C@H]([C@H]([C@H](C=O)O)O)O)OP(=O)([O-])[O-].[Na+].[Na+]
InChi Key	MSUSOPCULOEKKB-LMQMBFIUSA-L
InChi Code	InChI=1S/C5H11O8P.2Na/c6-1-3(7)5(9)4(8)2-13-14(10,11)12;;/h1,3-5,7-9H,2H2,(H2,10,11,12);;/q;2*+1/p-2/t3-,4+,5-;;/m0../s1
Chemical Name	disodium;[(2R,3R,4R)-2,3,4-trihydroxy-5-oxopentyl] phosphate
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	Human Endogenous Metabolite
ln Vitro	It is commonly accepted that both oxidative and non-oxidative pentose phosphate pathways can create ribose-5-phosphate [1].
References	[1]. Ribose-5-phosphate biosynthesis in Methanocaldococcus jannaschii occurs in the absence of a pentose-phosphate pathway. J Bacteriol. 2005 Nov;187(21):7382-9.
Additional Infomation	See also: d-ribose, 5-(dihydrogen phosphate), disodium salt (annotation moved to).

Solubility Data

Solubility (In Vitro)	H2O : 83.33 mg/mL (304.05 mM)
Solubility (In Vivo)	Solubility in Formulation 1: 100 mg/mL (364.87 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.6487 mL	18.2435 mL	36.4870 mL
	5 mM	0.7297 mL	3.6487 mL	7.2974 mL
	10 mM	0.3649 mL	1.8244 mL	3.6487 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.