D-69491 hydrochloride is a HER-2 tyrosine kinase activity inhibitor, inhibits HER-2 phosphorylation, inhibits SKOV-3 cell proliferation, and has anti-tumor activity.

Physicochemical Properties

Molecular Formula	C25H26CL2FN7O3
Molecular Weight	562.42
CAS #	346599-65-3
SMILES	CC1=C(NC(=C1)C(=O)NCCN2CCOCC2)C=C3C4=C(NC3=O)N=CN=C4NC5=CC(=C(C=C5)F)Cl.Cl
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	HER2
References	[1]. Inhibition of HER-2 by three independent targeting strategies increases paclitaxel resistance of SKOV-3 ovarian carcinoma cells. Naunyn Schmiedebergs Arch Pharmacol. 2005 Feb;371(2):141-51.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.7780 mL	8.8902 mL	17.7803 mL
	5 mM	0.3556 mL	1.7780 mL	3.5561 mL
	10 mM	0.1778 mL	0.8890 mL	1.7780 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.