GSK248233A is a dual inhibitor of Fluc and VEGFR2 with IC50 of 1.03 μM and 2 nM, respectively. GSK248233A also shows activity against the AGC family. GSK248233A acts as a protein kinase inhibitor across ATP-dependent and -independent luciferases, with potential effects on Fluc reporter gene assays.

Physicochemical Properties

Molecular Formula	C25H24N8O3
Molecular Weight	484.51
CAS #	850665-21-3
SMILES	C(NC1=CC=CC(OC2N=CC3N=C(C4C(N)=NON=4)N(CC)C=3C=2)=C1)(=O)C1=CC=C(N(C)C)C=C1
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Profile of the GSK published protein kinase inhibitor set across ATP-dependent and-independent luciferases: implications for reporter-gene assays. PLoS One. 2013;8(3):e57888.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.0639 mL	10.3197 mL	20.6394 mL
	5 mM	0.4128 mL	2.0639 mL	4.1279 mL
	10 mM	0.2064 mL	1.0320 mL	2.0639 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.