Cox B-IN-1 (7a) exhibits antiviral activity against Coxsackie B virus (Cox B). Cox B-IN-1 (7a) has dual activity, inhibiting both viral attachment and viral replication. Cox B-IN-1 (7a) shows great potential as a Coxsackievirus 3C protease inhibitor.

Physicochemical Properties

Molecular Formula	C38H32N10O2S2
Molecular Weight	724.86
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Synthesis, characterization, molecular docking, pharmacokinetics, and molecular dynamics of new bis-thiazoles based on bis-thiosemicarbazone as anti-coxsackievirus. Sci Rep. 2024 Nov 26;14(1):29378.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.3796 mL	6.8979 mL	13.7958 mL
	5 mM	0.2759 mL	1.3796 mL	2.7592 mL
	10 mM	0.1380 mL	0.6898 mL	1.3796 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.