Clofarabine-5'-diphosphate trisodium (Clofarabine-DP trisodium) is the sodium salt form of Clofarabine-5'-diphosphate. Clofarabine-5'-diphosphate trisodium is a metabolite of Clofarabine phosphorylated by deoxycytidine kinase (dCK). Clofarabine-5'-diphosphate trisodium can be further phosphorylated to Clofarabine-5'-triphosphate and exhibits cytotoxicity in cancer cells by inhibiting DNA synthesis and DNA repair.

Physicochemical Properties

Molecular Formula	C10H10CLFN5NA3O9P2
Molecular Weight	529.58
Related CAS #	Clofarabine-5'-diphosphate;167620-89-5
Synonyms	Clofarabine-DP trisodium
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Deoxycytidine kinase modulates the impact of the ABC transporter ABCG2 on clofarabine cytotoxicity. Cancer Res. 2011 Mar 1;71(5):1781-91.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.8883 mL	9.4414 mL	18.8829 mL
	5 mM	0.3777 mL	1.8883 mL	3.7766 mL
	10 mM	0.1888 mL	0.9441 mL	1.8883 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.