Cefminox Sodium (MT-141; Meicelin) is a potent penicillin binding protein inhibitor and a semisynthetic cephamycin with a broad spectrum of antibacterial activity. Also acting as a dual prostacyclin receptor (IP) and PPARγ agonist.
Physicochemical Properties
| Molecular Formula | C16H20N7NAO7S3 |
| Molecular Weight | 541.5478 |
| Exact Mass | 541.048 |
| CAS # | 75498-96-3 |
| Related CAS # | (6R,7S)-Cefminox sodium heptahydrate;92636-39-0 |
| PubChem CID | 60196336 |
| Appearance | White to off-white solid powder |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 14 |
| Rotatable Bond Count | 11 |
| Heavy Atom Count | 34 |
| Complexity | 869 |
| Defined Atom Stereocenter Count | 3 |
| SMILES | [Na+].OC(C(CSCC(N[C@@]1(C(=O)N2C(=C(CS[C@H]12)CSC1=NN=NN1C)C([O-])=O)OC)=O)N)=O |
| InChi Key | SBIDXLKJYJVQOE-ZMUPEPPLSA-M |
| InChi Code | InChI=1S/C16H21N7O7S3.Na/c1-22-15(19-20-21-22)33-4-7-3-32-14-16(30-2,13(29)23(14)10(7)12(27)28)18-9(24)6-31-5-8(17)11(25)26/h8,14H,3-6,17H2,1-2H3,(H,18,24)(H,25,26)(H,27,28)/q+1/p-1/t8?,14-,16+/m1./s1 |
| Chemical Name | sodium (6R,7S)-7-(2-((2-amino-2-carboxyethyl)thio)acetamido)-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate |
| Synonyms | MT141MT-141 Cefminox SodiumMT 141 Meicelin |
| HS Tariff Code | 2934.99.9001 |
| Storage |
Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Shipping Condition | Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs) |
Biological Activity
| References | :Antimicrob Agents Chemother. 1984 Nov;26(5):722-9. |
| Additional Infomation |
Cefminox Sodium is the sodium salt form of cefminox, a semi-synthetic, second-generation, beta-lactamase-stable cephalosporin with antibacterial activity. See also: Cefminox Sodium (preferred). |
Solubility Data
| Solubility (In Vitro) | H2O : ~83.33 mg/mL (~153.87 mM) |
| Solubility (In Vivo) |
Solubility in Formulation 1: 50 mg/mL (92.33 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.8466 mL | 9.2328 mL | 18.4655 mL | |
| 5 mM | 0.3693 mL | 1.8466 mL | 3.6931 mL | |
| 10 mM | 0.1847 mL | 0.9233 mL | 1.8466 mL |