CDK2 degrader 5 (compound 12) is a CDK2 degrader with a Dmax of greater than 50% and less than or equal to 80% in HiBiT assay. CDK2 degrader 5 plays an important role in cancer research.

Physicochemical Properties

Molecular Formula	C29H27N3O5
Molecular Weight	497.54
CAS #	2923574-11-0
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	CDK2
References	[1]. Monte Rosa Therapeutics, Inc. Preparation of 3-(6-substituted-1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives that mediate the degradation of cyclin-dependent kinase (CDK2) and are useful in the treatment of various disorders, such as cancer. World Intellectual Property Organization, WO2023069700 A1 2023-04-27https://patents.google.com/patent/US20240299559A1/en?oq=US20240299559A1.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.0099 mL	10.0494 mL	20.0989 mL
	5 mM	0.4020 mL	2.0099 mL	4.0198 mL
	10 mM	0.2010 mL	1.0049 mL	2.0099 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.