Bromperidol (R-11333) HCl has antipsychotic activity and has high affinity for central dopamine receptors D2. Bromperidol HCl and Spectinomycin can synergistically kill Mycobacteria.

Physicochemical Properties

Molecular Formula	C21H24BRCLFNO2
Molecular Weight	456.78
Exact Mass	455.066
CAS #	59453-24-6
Related CAS #	Bromperidol;10457-90-6
PubChem CID	164517260
Appearance	White to off-white solid powder
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	6
Heavy Atom Count	27
Complexity	451
Defined Atom Stereocenter Count	0
InChi Key	XAYXCUZHMISKSM-UHFFFAOYSA-N
InChi Code	InChI=1S/C21H23BrFNO2.ClH/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16;/h3-10,26H,1-2,11-15H2;1H
Chemical Name	4-[4-(4-bromophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one;hydrochloride
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

ln Vivo	In addition to inhibiting conditioned responses and learnt intracranial self-stimulation in rats, bromoperidol hydrochloride can counteract stereotyped behaviors and agitation brought on by apomorphine or amphetamine [1]. In dogs, apomorphine-induced vomiting can be countered and the conditioned avoidance response can be inhibited by bromperidol hydrochloride [1].
References	[1]. Benfield P, et al. Bromperidol. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in psychoses. Drugs. 1988 Jun;35(6):670-84. [2]. Ramón-García S, et al. Synergistic drug combinations for tuberculosis therapy identified by a novel high-throughput screen. Antimicrob Agents Chemother. 2011 Aug;55(8):3861-9.

Solubility Data

Solubility (In Vitro)

DMSO : ≥ 100 mg/mL (~218.92 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (5.47 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.1892 mL	10.9462 mL	21.8924 mL
	5 mM	0.4378 mL	2.1892 mL	4.3785 mL
	10 mM	0.2189 mL	1.0946 mL	2.1892 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.