BC11-38 is a potent, selective, and bioactive PDE11 inhibitor (antagonist) with IC50s of 0.28 µM and >100 µM for PDE11 and PDE1-10, respectively. BC11-38 increases cAMP levels, PKA-mediated ATF-1 phosphorylation, and cortisol production in H295R cells.

Physicochemical Properties

Molecular Formula	C15H16N2OS2
Molecular Weight	304.430340766907
Exact Mass	304.07
CAS #	686770-80-9
PubChem CID	2052828
Appearance	White to yellow solid powder
LogP	3.382
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	4
Heavy Atom Count	20
Complexity	453
Defined Atom Stereocenter Count	0
InChi Key	YHNDCCKFNWDQGW-UHFFFAOYSA-N
InChi Code	InChI=1S/C15H16N2OS2/c1-2-9-20-15-16-12-8-10-19-13(12)14(18)17(15)11-6-4-3-5-7-11/h3-7H,2,8-10H2,1H3
Chemical Name	3-phenyl-2-propylsulfanyl-6,7-dihydrothieno[3,2-d]pyrimidin-4-one
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

ln Vitro	H295R-initiated cells have higher cAMP levels when exposed to BC11-38 (20 μM; hr) [1].
References	[1]. Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen. Chem Biol. 2012;19(1):155-163.

Solubility Data

Solubility (In Vitro)

DMSO : ~33.33 mg/mL (~109.48 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (8.21 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.2848 mL	16.4241 mL	32.8483 mL
	5 mM	0.6570 mL	3.2848 mL	6.5697 mL
	10 mM	0.3285 mL	1.6424 mL	3.2848 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.